Ethanolic Seed Extract of Garcinia kola Reduces Epididymal Sperm Count and Some Serum Reproductive Hormone Concentrations in Adult Male Albino Wistar Rats

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Emmanuel C. Okafor
Agbai E. Onuka
Idiongo O. Umoh
Felix N. Ugwu

Abstract

Aims: This study aimed to elucidate the effect of Garcinia kola on serum reproductive hormones and sperm count in adult male albino Wistar rats.

Study Design:  Albino rats were randomly assigned into 4 groups containing 7 rats each.

Place and Duration of Study: Department of Human Physiology, Madonna University, Nigeria.

Methodology: Group 1 served as the control group, while groups 2, 3 and 4 received Garcinia kola extract orally at the rate of 100mg/kg, 200mg/kg and 300mg/kg body weight, respectively once daily for 6 weeks (n꞊7). After 6 weeks of treatment, reproductive hormonal assay was carried out using the rat serum. Epididymal spermatozoa were collected and sperm count was determined using heamocytometer.

Results: The experimental groups had significantly lower weights of testes (P<0.05), as compared with the control group. The weights of epididymis in the experimental groups where significantly (P<0.05) higher when compared to the control group. There was a significant decrease in the serum concentration of testosterone (P<0.05) in the experimental groups when compared to the control group. Semen analysis also showed a significant decrease in the sperm density (P<0.05) in the groups treated with Garcinia kola extract when compared to the control group.

Conclusion: Ethanolic seed extract of Garcinia kola showed a possible anti-spermatogenic consequence on treatment in male Wistar rats, and may be detrimental to male reproductive health, hence need to regulate its consumption rate.

 

Keywords:
Garcinia kola, epididymis, testosterone, sperm count, testes

Article Details

How to Cite
C. Okafor, E., E. Onuka, A., O. Umoh, I., & N. Ugwu, F. (2018). Ethanolic Seed Extract of Garcinia kola Reduces Epididymal Sperm Count and Some Serum Reproductive Hormone Concentrations in Adult Male Albino Wistar Rats. Asian Journal of Research in Medical and Pharmaceutical Sciences, 4(2), 1-5. https://doi.org/10.9734/AJRIMPS/2018/42640
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Original Research Article