Evaluation of the Binding Properties of a Polymer Obtained from Modification of Triticum aestivum Starch in Metronidazole Tablets Formulation

Main Article Content

Nkemakolam Nwachukwu
Kenneth Chinedu Ugoeze
Azuka Ijoma Alumona

Abstract

Aim: The binding properties of a polymer obtained from modification of Triticum aestivum (TA) starch in metronidazole tablets formulation were evaluated.

Study Design: Experimental design.

Place and Duration of Study: Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria from January to July, 2018.

Methods: TA seeds were steeped for 72 h, wet milled and the native Triticum aestivum starch (NTS) extracted. NTS (1kg) was oxidized by slurring in 4 L of 3.50% w/v sodium hypochlorite, washed to neutral pH with 95% v/v ethanol (MTS). MTS was dried at 60°C for 3 h, milled and classified (250 μm). The starches were characterized using standard methods and applied as binders at 1, 2 and 3% w/w in formulating metronidazole tablets using wet granulation. Methylcellulose and gelatin at similar concentrations were used as standards.

Results: The granules and tablets were evaluated using standard methods. NTS and MTS had similar properties with starch. The modification improved the densities, hydration capacity and flow properties of MTS. The granules flowed and compressed well. The tablets had minimal weight variation, hardness (≥ 4 kgF), friability (<1%) and disintegration (<15 min). Metronidazole release (≥ 85%) within 60 min existed in all the batches except batches containing 1% methylcellulose and 3% gelatine.

Conclusion: The results met with United States Pharmacopoeia specifications for oral uncoated metronidazole tablets. MTS performed better than NTS and compared well with methylcellulose and gelatin as binder in metronidazole tablet formulation.

Keywords:
Triticum aestivum, starch, binder, modification, metronidazole tablet.

Article Details

How to Cite
Nwachukwu, N., Ugoeze, K. C., & Alumona, A. I. (2021). Evaluation of the Binding Properties of a Polymer Obtained from Modification of Triticum aestivum Starch in Metronidazole Tablets Formulation. Asian Journal of Research in Medical and Pharmaceutical Sciences, 10(2), 13-31. https://doi.org/10.9734/ajrimps/2021/v10i230159
Section
Original Research Article

References

Chaudhari SP, Patil PS. Pharmaceutical excipients: A review. International Journal of Advances In Pharmacy, Biology And Chemistry. 2012;1(1):21-34.

Alison H. Pharmaceutical excipients – where do we begin?. Australian Prescriber. 2011;34(4):112-114.

Liu L, Chen G, Fishman ML, Hicks KB. Pectin gel vehicles for controlled fragrance delivery. Drug Deliv. 2005;12:149– 57.

Patel H, Shah V, Upadhyay U. New pharmaceutical excipients in solid dosage forms – A review. Int. J. Pharm. Life Sci. 2011;2(8):1006-1009.

Bhattarai M, Gupta AK. Fast dissolving oral films: A novel trend to oral drug delivery system. Sunsari Technical College Journal. 2015;2(1):58-68.

Chein YW. “Oral drug delivery and delivery systems” 2nd ed. New York: Marcel Dekker; 1992.

Chatterjee S, Mazumder R. “Novel approach of extraction and characterization of okra gum as a binder for tablet formulation”. Asian Journal of Pharmaceutical and Clinical Research. 2019,12(1):189-92.
DOI: 10.22159/ajpcr.2019.v12i1.29053.

Hussain A, Qureshi F, Abbas N, Arshad MS, Ali E. An evaluation of the binding strength of okra gum and the drug release characteristics of tablets prepared from it. Pharmaceutics. 2017;9(2):20.
DOI: https://doi.org/10.3390/pharmaceutics9020020.

Anwar Z, Gulfraz M, Arshad M. Agro-industrial lignocellulosic biomass a key to unlock the future bio-energy: A brief review. Journal of Radiation Research and Applied Sciences. 2014;7:163- 173.

Hartesi B, Sriwidodo Abdassah M, Chaerunisaa AY. Starch as pharmaceutical excipient. Int. J. Pharm. Sci. Rev. Res. 2016;41(2):59-64

Bos CE, Bolhuis GK, van Doorne H. et al. Native starch in tablet formulations: Properties on compaction. Pharmaceutisch Weekblad Scientific Edition.1987;9:274–282.
DOI: https://doi.org/10.1007/BF01953630

Kunle OO. Starch source and its impact on pharmaceutical applications; 2019.
DOI: http://dx.doi.org/10.5772/intechopen.89811

Emeje MO, Rodrigues A. In: Valdez B, editor. Starch: From food to medicine, scientific, health and social aspects of the food industry. InTech; 2012.
ISBN: 978-953-307-916-

Alcázar-Alay SC, Meireles MAA. Physicochemical properties, modifications, and applications of starches from different botanical sources. Food Science and Technology. 2015;35(2):215-236

Bertoft E. Understanding starch structure: Recent progress. Agronomy. 2017;7: 56.
DOI: 10.3390/ agronomy7030056

Waterschoot J, Gomand SV, Fierens E, Delcour JA. Production, structure, physicochemical and functional properties of maize, cassava, wheat, potato and rice starches. Starch/Staerke. 2015;67(1-2):14-29.

Musa H, Muazu J, Bhatia PG. Evaluation of fonio (Digitaria exilis) starch as a binder in paracetamol tablets. Nigerian Journal of Pharmaceutical Sciences. 2008;7(1):56-66.

Patil BS, Rao KD, Kulkarni U, Khalid MS, Korwar PG. Properties of zingiber officinale starch as a novel tablet binder. International Journal of Pharmaceutical Sciences. 2010;2(3):717- 723.

Ugoeze KC, Nwachukwu N. The disintegrant property of a hydrophilic cellulose polymer derived from the tubers of Ipomoea batatas in paracetamol tablet formulation. Journal of Advances in Medical and Pharmaceutical Sciences. 2017;15:1-9.

Ugoeze KC, Nwachukwu N. The effect of a novel hydrophilic biopolymer derived from Ipomoea batatas tuber as a granulating agent in paracetamol tablet properties. Journal of Drug Delivery and Therapeutics. 2018;8:112-117.

Ugoeze KC, Nwachukwu N, Anumaka FC, Ezioka GN. Studies on a hydrophilic cellulose matrix derived from Ipomoea batatas tubers I: Processing and physicochemical properties. Indo American Journal of Pharmaceutical Research. 2017;7:638-645.

Yadav A, Garg VK. Nutrient recycling from industrial solid wastes and weeds by vermin processing using earth worms. Pedo-Sphere. 2013;23(5):668- 677.
DOI: 10.1016/S1002-0160(13)60059-4.

Dura A, Rosell CM. Physico-chemical properties of corn starch modified with cyclodextrin glycosyltransferase. International Journal of Biological Macromolecules. 2016;87:466- 472.

Oluwole OI, Avwerosuoghene OM. Effects of cassava starch and natural rubber as binders on the flexural and water absorption properties of recycled paper pulp based composites. International Journal of Engineering and Technology Innovation. 2015;5:255- 263.

Adak S, Banerjee R. A green approach for starch modification: Esterification by lipase and novel imidazolium surfactant. Carbohydrate Polymers. 2016;150:359-368.

Majzoobi M, Farahnaky A, Amiri S. Physicochemical characteristics of starch component of wheat flours obtained from fourteen Iranian wheat cultivars. International Journal of Food Properties. 2011;14(4):685-696.

Shewry PR, Hey SJ. The contribution of wheat to human diet and health. Food and Energy Security. 2015;4(3):178- 202.

Odeniyi MA, Ayorinde JO. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. Polim Med. 2014;44(3):147-155.

Builders PF, Arhewoh MI. Pharmaceutical applications of native starch in conventional drug delivery. Starch/Stärke. 2016;68:1–10.

Isah S, Oshodi AA, Atasie VN. Physicochemical properties of cross linked acha (Digitaria exilis) starch with citric acid. Chem Int. 2017;3:150-157.

The United States Pharmacopeia and National Formulary USP 32–NF 27. The United States pharmacopeial convention. Inc.: Rockville, MD, USA; 2009.

Carstensen JT, Chan FC. Flow rates and repose angle of wet-processed granulations. J. Pharm. Sci; 1977;66: 1235.

Ring SG. Some studies on gelatin. Starch. 1985;37:80-87

Walter L (editor). The pharmaceutical codex. Principles and practice of pharmaceutics, 12th Ed. The Pharmaceutical Press, London. 1994; 696.

Zeleznik JA, Renak JL. ‘‘Flow and compaction properties of dibasic calcium phosphate blended with microcrystalline cellulose and silicified microcrystalline cellulose’’. A Paper Presented at the American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Denver, Colorado; 2001.

British Pharmacopoeia. Her Majesty’s Stationery Office, London; 2012

Hausner HH. Friction conditions in a mass of metal powder. J. Powder Metal. 1967;3:7-13.

Thoorens G, Krier F, Leclercq B, Evrad B. Microcrystalline cellulose, a direct compression binder in a quality by design environment-A review. Int. J. Pharmaceutics. 2014;473: 64- 72.

Sair L, Fetzer WR. Water sorption by starches. Ind Eng Chem. 1944;36:205–208. DOI: 10.1021/ie50411a004.

Chitedze J, Monjerezi M, JD Kalenga Saka, Jan Steenkamp. Binding effect of cassava starches on the compression and mechanical properties of ibuprofen tablets. Journal of Applied Pharmaceutical Science. 2012;2(4):31-37.