Asian Journal of Research in Medical and Pharmaceutical Sciences 2020-02-27T17:38:26+00:00 Asian Journal of Research in Medical and Pharmaceutical Scie Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Medical and Pharmaceutical Sciences&nbsp;(ISSN: 2457-0745)</strong>&nbsp;aims to publish research papers, reviews and short communications in the areas of&nbsp;medical and pharmaceutical sciences. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. This journal will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. This journal is novelty attracting, open-minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Ureter Kinked around the Superior Mesenteric Vein Causing Features of Pelviureteric Junction Obstruction: A Case Report 2020-02-27T17:38:25+00:00 Ramesh Bharti Rajesh Chaudhary Amar Verma Rajesh Sharma Amit Dogra Saloni Sood <p>Pelviureteric junction obstruction (PUJO) is the condition where flow of urine from the renal pelvis to the ureter is hindered due to various intrinsic or extrinsic causes. Lower pole renal vessels are mostly associated with this condition. Unlike our case, there have been reports of ureter being kinked around the Veins of Retzius but there has been no case report of ureter being kinked around the superior mesenteric vein directly causing features of PUJO.</p> 2020-01-23T00:00:00+00:00 ##submission.copyrightStatement## Ameliorative Effect of Pleurotus ostreatus on Lipid Levels and Atherogenic Indices in Hyperlipidemic Rats 2020-02-27T17:38:26+00:00 N. L. Nwobi O. S. Usiobeigbe R. O. Osaro J. C. Nwobi <p><strong>Aim:</strong> To evaluate the effects of <em>Pleurotus ostreatus</em> on the lipid profile and atherogenic indices in Hyperlipidemic rats.</p> <p><strong>Study Design, Place and Duration of Study:</strong> This case-control study was done for 60 days between March and April, 2017 at the department of Medical Laboratory Science and Department of Chemical Pathology, Babcock University, Ogun State, Nigeria.</p> <p><strong>Methodology:</strong> Thirty male wistar rats weighing 117-130 g were divided randomly into 3 groups: Normolipidemic (NL) rats (fed with standard rodent chow), Hyperlipidemic (HL) rats (fed with standard rodent chow + duck yolk and reused oil), Hyperlipidemic Treated (HL+T) rats (fed with standard rodent chow + duck yolk and reused oil + 5% <em>Pleurotus ostreatus </em>powder).&nbsp;</p> <p>Changes in the animal body weights were measured in this study. Serum was obtained from fasting blood samples for the standard biochemical analyses of total cholesterol (TC), triglycerides (TG), High density lipoprotein cholesterol (HDL-C), creatinine, urea, Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST). Low density lipoprotein (LDL), very low density lipoprotein (VLDL), TC/HDL, LDL/HDL and Log (TG/HDL) ratios were calculated.</p> <p><strong>Results:</strong> The HL+T rats compared to HL rats had significantly reduced body weight, TC, TG, LDL, VLDL, TC/HDL, LDL/HDL and Log(TG/HDL) by 19.59%, 14.38%, 15.82%, 25.52%, 15.83%, 28.89%, 20.24% and 27.27% respectively (p ≤ 0.05) but recorded no significant change in HDL-C (p &gt; 0.05). Creatinine, urea, AST and ALT did not show any significant change in HL rats and HL+T rats (p &gt; 0.05).</p> <p><strong>Conclusion:</strong> Treatment of hyperlipidemic male wistar rats with <em>Pleurotus ostreatus</em> reduced body weight, lipid levels (TC, TG, LDL, VLDL) and atherogenic indices (TC/HDL, LDL/HDL, Log (TG/HDL)) and appeared to have no detrimental effects on the liver and kidneys. These findings may provide insights and scientific basis for the promotion of the use of <em>Pleurotus ostreatus</em> in controlling hyperlipidemia and associated complications.</p> 2019-12-21T00:00:00+00:00 ##submission.copyrightStatement## Protective Role of Rockect Seed (Eruca sativa) Extract against Monosodium Glutamate-induced Hepato-renal Toxicity in Male Rats 2020-02-27T17:38:26+00:00 Ehab Tousson Afaf El-Atrash Yosra Karson <p><strong>Background and Objective:</strong> Monosodium glutamate (MSG) is identified as an Accent that is used in the food industry as a flavour enhancer with an umami taste that intensifies the meaty, savoury flavour of food. The present study aimed at evaluating the protective and ameliorative role of rocket seeds extract against monosodium glutamate-induced hepatic renal toxicity and oxidative stress in the male rat.</p> <p><strong>Materials and Methods</strong><strong>:</strong> A total of 60 male adult albino rats were equally divided into six groups (G1, Control; G2, rocket seeds (RS); G3, ACCENT or MSG; G4, Co- treated (RS+MSG); G5, Post- treated (MSG+RS); G6, Self-treated MSG).&nbsp;</p> <p><strong>Results:</strong> Current results revealed that; a significant increase in serum ALT, AST, ALP, AFP, Urea, Creatinine, potassium ions, chloride ions, cholesterol, triglyceride, HDL, and LDL levels in MSG as compared to control and RS groups. In contrast; a significant decrease in serum albumin, total proteins, catalase, GSH and SOD in liver and kidney homogenates in MSG as compared to control and RS groups. Co- or post-treatment of MSG with rocket seeds improved this change in liver and kidney functions, with best results for co-treatment than post and self-treatment.</p> <p><strong>Conclusion:</strong> These findings suggested that the misuse of monosodium glutamate may contribute to continuous hepatic and renal damage. This shows that the desired dose of monosodium glutamate can safely be used with grapes seed in improving hepatic and renal damage in monosodium glutamate in young rats.</p> 2020-01-04T00:00:00+00:00 ##submission.copyrightStatement##