The Effects of Combined Ethanolic Leaf Extracts of Annona muricata and Artocarpus heterophyllus on Reproductive Parameters of Type 2 Diabetic Wistar Albino Rats
F. C. Anacletus *
Department of Biochemistry, Faculty of Science, University of Port Harcourt, P.M.B. 5323, East-West Road, Choba, Rivers State, Nigeria.
C. L. Onuah
Department of Biochemistry, Faculty of Science, University of Port Harcourt, P.M.B. 5323, East-West Road, Choba, Rivers State, Nigeria.
K. T. Nwauche
Department of Chemical Sciences, Biochemistry Unit, College of Basic and Applied Sciences, Rhema University, P.M.B. 7021, Aba, Abia State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim of this research is to study the combined effects of the ethanolic leaf extracts of Annona muricata and Artocarpus heterophyllus on the reproductive parameters of type II diabetic wistar albino rats.
Materials and Methods: Fifty-six (56) male wistar albino rats were induced with Type II diabetes mellitus using high fat diet and 35 mg/kg body weight streptozotocin (HFD-STZ).
Results: The result obtained showed a decreased testosterone level 0.78±.06 ng/ml on the diabetic group while the non-diabetic group had testosterone level of 1.90±.09 ng/ml. Treatment with combined ethanol leaf extract of A. muricata and A. heterophyllus led to a significant (p≤0.05) increase in the testosterone level of the treated groups. The motility, viability and the sperm density were also normalised in the treated groups.The result obtained from the present research showed that combined ethanolic leaf extracts of A. muricata and A. heterophyllus has ameliorative effect of the reproductive parameters of type II diabetic male wistar albino rats.
Keywords: Fertility, diabetes mellitus, Annona muricata, Artocarpus hetrophyllus, phytochemical