Hydroxicloroquine, What is the Role of the Drug in the Treatment of COVID-19? A Review
Eliza Miranda Ramos *
Spectroscopy and Bioinformatics Group Applied to Biodiversity and Health, Faculty of Medicine, Graduate Program in Health and Development in the Midwest Region, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil and Fundation Brazil – CAPES, Brazil.
Francisco José Mendes dos Reis
Spectroscopy and Bioinformatics Group Applied to Biodiversity and Health, Faculty of Medicine, Graduate Program in Health and Development in the Midwest Region, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Gilberto Gonçalves Facco
Graduate Program in Environments and Regional Development, Anhanguera University, UNIDERP, Mato Grosso do Sul, Brazil.
Emerson Luiz Lima Araújo
Ministry of Health, Secretary of Health Surveillance, Department of Strategic Coordination of Health Surveillance, General Coordination of Public Health Laboratories, Brasília-DF, Brazil.
Igor Domingos de Souza
Anhanguera University Center of Campo Grande - MS, Superior Course of Technology in Radiology, Mato Grosso do Sul, Brazil.
Glícia Caroline Andrade Ramos
Secretary of State for Health of the Federal District, Brasília - DF, Brazil.
Alessandro Carvalho da Fonseca
Brazilian Hospital Services Company - EBSERH/Dourados, Mato Grosso do Sul, Brazil.
Iara Barbosa Ramos
Centro Universitário Anhanguera de Campo Grande - MS, Nursing Course, Mato Grosso do Sul, Brazil.
Hugo Vieira Ramos
Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Valter Aragão do Nascimento
Spectroscopy and Bioinformatics Group Applied to Biodiversity and Health, Faculty of Medicine, Graduate Program in Health and Development in the Midwest Region, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Coronaviruses (COVID-19) is an emerging virus with severe respiratory infection. Despite several efforts, so far there is no medicine to fight it and use it as the ideal treatment. OBJECTIVES: This study aims to describe the role of hydroxychloroquine in the treatment of patients with COVID-19 and thus present its benefits in the respective doses.
Methodology: The methodology used was the systematic review with meta-analysis.
Results: From the reading of the 75 papers found, only three articles were excluded for not presenting a complete abstract, 65 were excluded for not presenting eligibility according to the inclusion criteria, 01 was excluded for reaching a methodological score below 20 points in Down and Black (1998) and ending the process of inclusion of the articles, only 06 articles were included and included 894 patients.
Conclusion: Despite the small number of published articles, this meta-analysis found that the use of hydroxychloroquine as an adjunct therapy in the follow-up of COVID-19 in patients with mild to severe clinical signs brings benefits and avoids hospitalization in intensive care.
Keywords: Hydroxychloroquine, COVID-19, extension QT, hospitalization, viremia