A Review on Benzothiazole Derivatives and Their Biological Significances

Rima Mahapatra *

Department of Pharmaceutical Chemistry, Bharat Technology, Uluberia, Howrah, West Bengal, India.

Kuntal Hazra

Department of Pharmaceutical Chemistry, Bharat Technology, Uluberia, Howrah, West Bengal, India.

*Author to whom correspondence should be addressed.


Abstract

Benzothiazole is a molecule that has a wide range of pharmacological activities. The addition of a fluorine atom into the structure of benzothiazole enhances the various activities of the drug as the alteration of hydrogen or oxygen atom from a carbon bond by a fluorine atom improves desirable pharmacological properties such as greater biological half-life, higher ability to bind with the targeted receptor, and also enhances the lipophilic character of the drug. The special property that makes fluorine a very important molecule in the drug discovery includes a very small radius of the fluorine atom, a higher attacking power towards electrons, and a very low polarizability of the fluorine atom. Literature reveals that strong electron-attacking groups like fluorine in the structure of benzothiazole can exhibit anticancer activity of the drug, benzothiazole with Sulphonamide or with beta-lactam ring enhances the anti-inflammatory and antioxidant activity. Benzothiazole with oxadiazole shows potent anthelmintic activity [1-5].

Keywords: Benzothiazole, oxadiazole, sulphonamide, anthelmintic


How to Cite

Mahapatra , R., & Hazra , K. (2023). A Review on Benzothiazole Derivatives and Their Biological Significances. Asian Journal of Research in Medical and Pharmaceutical Sciences, 12(1), 13–19. https://doi.org/10.9734/ajrimps/2023/v12i1206

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