A Review on Benzothiazole Derivatives and Their Biological Significances

Rima Mahapatra *

Department of Pharmaceutical Chemistry, Bharat Technology, Uluberia, Howrah, West Bengal, India.

Kuntal Hazra

Department of Pharmaceutical Chemistry, Bharat Technology, Uluberia, Howrah, West Bengal, India.

*Author to whom correspondence should be addressed.


Benzothiazole is a molecule that has a wide range of pharmacological activities. The addition of a fluorine atom into the structure of benzothiazole enhances the various activities of the drug as the alteration of hydrogen or oxygen atom from a carbon bond by a fluorine atom improves desirable pharmacological properties such as greater biological half-life, higher ability to bind with the targeted receptor, and also enhances the lipophilic character of the drug. The special property that makes fluorine a very important molecule in the drug discovery includes a very small radius of the fluorine atom, a higher attacking power towards electrons, and a very low polarizability of the fluorine atom. Literature reveals that strong electron-attacking groups like fluorine in the structure of benzothiazole can exhibit anticancer activity of the drug, benzothiazole with Sulphonamide or with beta-lactam ring enhances the anti-inflammatory and antioxidant activity. Benzothiazole with oxadiazole shows potent anthelmintic activity [1-5].

Keywords: Benzothiazole, oxadiazole, sulphonamide, anthelmintic

How to Cite

Mahapatra , R., & Hazra , K. (2023). A Review on Benzothiazole Derivatives and Their Biological Significances. Asian Journal of Research in Medical and Pharmaceutical Sciences, 12(1), 13–19. https://doi.org/10.9734/ajrimps/2023/v12i1206


Download data is not yet available.


Gurupadayya BM, Sambireddy CH, Purohit MN, Pujar GV. Synthesis and pharmacological evaluation of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2- aryldenylamino)benzo(1,3)thiazoles, J. Sci. Res. 2011;3(1):121-128.

Reddy DRS, Raparla LP, Karakavalasa Pradeep, Ahmed SM, Sindhura J. Synthesis, analytical characterization, antimicrobial, antioxidant and anticonvulsant evaluation of some novel 6-fluoro benzothiazole substituted pyrazole analogs. IJPC. 2013; 03(04):72-81.

Meti N, Kuntal H, Nargund LVG, Rashmi P. Synthesis and evaluation of some new ß-lactam rings containing benzothiazole derivatives as potential antimicrobial agents but less potent antioxidant agents. J. Pharm. Res. 2011;4(10):3409-3413.

Ojima I. Strategic incorporation of fluorine into taxoid anticancer agents for medicinal chemistry and chemical biology studies. J. Fluor. Chem. 2017;198:10–23.

Smart BE. Fluorine substituent effects (on bioactivity). J. Fluor. Chem. 2001;109:3–11.

Omar MME, et al. Design, facile synthesis, and anthelmintic activity of new O-substituted 6 methoxy benzothiazole-2- carbamates. Part II, Med. Chem. Commun. 2017;8:1440-1451.

Liu R, et al. Hydride-induced meisenheimer complex formation reflects the activity of nitro aromatic antituberculosis compounds. RSC Med. Chem. 2021;12:62-72.

Al-Harthy T, Zoghaib W, Jalil RA. Review on importance of fluorine in benzazole compounds, molecules. 2020;25:4677.

Naresh P, Pattanaik P, Rajeshwar B. Synthetic characterization and antioxidant screening of some novel 6 fluorobenzothiazole substituted [1, 2, 4] triazole analogues. Int. J. Pharma Sci. 2013;3(2):170-174.

Naresh P, Pattanaik P, Priyadarshini RL, Reddy DR. Synthetic characterization & antimicrobial screening of some novel 6-fluorobenzothiazole substituted [1, 2, 4] triazole analogues. Int. J. Pharm. Res. and Health Sci. 2013;1(1):18-25.

Tzanova T, Gerova M, Petrov O, Karaivanova M, Bagrel D. Synthesis and antioxidant potential of novel synthetic benzophenone analogs. Eur. J. Med. Chem. 2008:1–7.

Pathak N, Rathi E, Kumar N, Kini SG, Rao CM. Review on anticancer potentials of benzothiazole derivatives, mini-reviews in medicinal chemistry. 2020;20:12-23.

Irfan A, et al. Review article, benzothiazole derivatives as anticancer agents. J. Enzyme Inhib. Med. Chem. 2020;35(1):265–279.

Catalano A, et al. Benzothiazole-containing analogues of triclocarban with potent antibacterial activity, antibiotics. 2021;10:803.

Su X, et al. Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1, Mol. Cell. Endocrinol. 2006;248:214–217.

Morales-Garcia JA, et al. Biological and pharmacological characterization of benzothiazole based ck-1δ inhibitors in models of Parkinson’s disease. ACS Omega. 2017;2:5215−5220.

Gupta A, Rawat S. Synthesis and anti-inflammatory study of novel fluoro benzothiazole derivatives. J. Chem. Pharm. Res. 2010;2(5):244-258.

Neumaier B, Deisenhofer S, Sommer C, Solbach C, Reske SN, Mottaghy F. Synthesis and evaluation of 18F-fluoroethylene benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer’s disease. Appl Radiat Isot. 2010;68:1066–1072.