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This study was designed to determine the antibiogram of bacteria isolated from post - operative wound samples of mothers who underwent caesarean section at the Mother and Child Hospital, Akure. The collected samples were subjected to microbiological analysis and bacterial isolates were identified using conventional identification techniques. The antibiotic sensitivity profile of the bacterial isolates to commercially available antibiotics was determined using disc diffusion technique. Chloramphenicol, Ampiclox (Ampicillin and Cloxacillin), Levofloxacin, Ciprofloxacin, Gentamicin, Norfloxacin, Amoxicillin, Streptomycin, Rifampicin, and Erythromycin were the antibiotics used for Gram positive bacteria while Ofloxacin, Pefloxacin, Ciprofloxacin, Augmentin, Gentamycin, Streptomycin, Cephem (cephalosporins and cephamycins), NA- Nalidixic acid, Trimethoprim-Sulfamethoxazole, PN-ampicillin were the antibiotics used for Gram negative bacteria. Results obtained showed that Staphylococcus aureus, Pseudomonas aeruginosa, Proteus sp and E. coli are the most frequently isolated strains from post - operative wound samples analyzed. Moreover, most of the isolates displayed multi drug resistance to the conventional antibiotics used. This study has shown that multi drug resistant pathogenic organisms are predominant in post-operative caesarean wounds amongst the patients sampled. The study also revealed that the implication of this is the tendency of such wounds to become septic and life threatening to the patients. This study also revealed that levofloxacin had the highest inhibitory effect on S. aureus while Ciprofloxacin had the highest inhibitory effect on P. aeruginosa, Proteus so. and E. coli. Therefore, these antibiotics can be recommended for cases of nosocomial infections associated with Post Caesarean wounds. Hospitals must give measures to restrict hygienic in hospitals to prevent bacterial contamination and development of more effective chemotherapeutic drugs against multi-drug resistant bacteria must be done.