Standardization of Gandhaga Thailam: A Traditional Siddha Formulation for Skin Disorders

R. Sathish Adithya

Department of Nanju Maruthuvam, National Institute of Siddha, Chennai-47, India and Department of Siddha, Tamil Nadu Dr. MGR Medical University, Chennai-69, India.

E. M. Manikgantan *

Department of Siddha, Tamil Nadu Dr. MGR Medical University, Chennai-69, India.

N. Kabilan

Department of Siddha, Tamil Nadu Dr. MGR Medical University, Chennai-69, India.

S. Kanimozhi

Sri Sairam Siddha Medical College and Research Centre, Chennai-44, India.

*Author to whom correspondence should be addressed.


Abstract

Standardization is a part of Drug development process. Identifying the quality of a Siddha formulation is essential before it taken up for In vivo, In vitro studies and Clinical trials. Gandhaga thailam a Mineral based Siddha medicine to treat various ailments like Eczema, Ulcer, Peptic ulcer diseases etc. Test samples were extracted with acetone and briefly homogenized. Further filtration followed by addition of acetone to the test mixture. The test samples were heated using a rotary evaporator at a temperature not exceeding 40°C until almost complete evaporation of the solvent. HPTLC analysis reveals the presence of thirteen prominent peaks corresponds to the presence of thirteen versatile phytocomponents present within it. Rf value of the peaks ranges from 0.02 to 0.80. Study indicates that the Gandhaga Thailam is in standard quality, hence the preparation and purification processes of ingredients were done as per the literature.  With these results Gandhaga thailam may be subjected to invitro and invivo toxicity studies in future. Results reveal the quality of the Medicine Gandhaga Thailam and may be the fingerprint for the future analysis on Gandhaga Thailam.

Keywords: Pharmacology, traditional medicine, Ghandhaga Thailam, siddha, standardization


How to Cite

Adithya , R. S., Manikgantan, E. M., Kabilan, N., & Kanimozhi, S. (2024). Standardization of Gandhaga Thailam: A Traditional Siddha Formulation for Skin Disorders. Asian Journal of Research in Medical and Pharmaceutical Sciences, 13(1), 68–76. https://doi.org/10.9734/ajrimps/2024/v13i1248

Downloads

Download data is not yet available.

References

Deore et al., The Stages of Drug Discovery and Development Process; Asian Journal of Pharmaceutical Research and Development. 2019:7(6):62-67.

Agasthiar Paripooranam 400; Author: R.M.K. Thirumalaisamypillai; Published in. 1994;155:156.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;252.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;363-364.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;286.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;336.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;240.

Siddha MateriaMedica (Mineral and Animal Kingdom). Published in: Dr. Anaivaari R. Anandan, First Edition. 2008;36.

CCRS_Guidline of Drug_Book-7_CD MATTER.pdf (ccras.nic.in)

India Pharmacopeia I Volume I, Government of India, Ministry of Health and Family welfare, Indian Pharmacopeia commission; 2014.

Indian standard methods of sampling and test for oils and fats Indian standard institution New Delhi. 1964;47-50.

Rajeswari K. et al. Physicochemical Standardisation of Siddha Tablet Preparation JathikaaiMathirai; Int. J. Res. Ayurveda Pharm. 2021;12(4):87-93.

Parvathy Mohan et al, Pharmacopoeial Standards of Snehakalpana; JETIR, December. 2020; 7(12):80-82.

Arunadevi R. et al. Preparation and standardization of Mathan Tailam: A classical Siddha formulation for diabetic ulcerative wound healing; Journal of Ayurveda and Integrative Medicine. 2020; 11:10-15.

Great Iruoghene Edo, et al. Physicochemical and Pharmacological Properties of Palm Oil: an Approach for Quality, Safety, and Nutrition Evaluation of Palm Oil; n Food Analytical Methods; 2022.

DOI: 10.1007/s12161-022-02293-4

Hassan F, Edo GI, Nwosu LC et al. An inventory of medicinal plants used as sedative, analgesic and blood tonic in Abeokuta, Ogun State. Nigeria Acta Ecol Sin; 2021 Available:https://doi.org/10.1016/j. chnaes.2021.11.003

Hewageegana HGSP et al,Standardization of Vipadikahara ghrita thaila: An Ayurvedic medicated oil for common skin lesions;Unique journal of Ayurvedic and Herbal Medicines. 2013;01(01):48-51.

M.M Srivastava et al., Identification and quantification of amino acids in coconut water using high performance thin layer chromatographic method; Analytical Chemistry an Indian Journal. 2011; 10(7):440-443.

Roopa Rani et al., HPTLC-MS analysis of melamine in milk: standardization and validation; Dairy Sci. & Technol. 2015;95: 257–263. DOI 10.1007/s13594-014-0204-3.

Prawez Alam, Densitometric HPTLC analysis of 8-gingerol in Zingiber officinale extract and ginger-containing dietary supplements, teas and commercial creams; Asian Pacific Journal of Tropical Biomedicine. 2013;3(8):634-638. DOI:10.1016/S2221-1691(13)60128-8.

Syed Shariq Mian et al., Physicochemical Analysis of Ginger (Zingiber officinale Rosc.) Rhizome along with its TLC, HPLC and HPTLC Profile; Pharm Methods. 2019;10(1):31-36.

DOI:10.5530/phm.2019.1.6

Karthika T. Clinical Evaluation of the Effect of Akkara Nei for the treatment of Vaai Akkaram (Doctoral dissertation, Government Siddha Medical College, Palayamkottai).