Modulation of Obesity in Sub-Saharan Africa Using Coenzyme Q10
Asian Journal of Research in Medical and Pharmaceutical Sciences,
Obesity is a metabolic disease caused by a large buildup of fat in the body and a deficit in energy consumption compared to energy disposal. It has been related to a shorter life expectancy, has been connected to various cancer types, and has been linked to secondary metabolic illnesses such as diabetes, atherosclerosis, and hypertension. Due to an increase in white adipose tissue deposition, oxidative stress can lead to obesity, and obesity can lead to increased oxidative stress in the body. Coenzyme Q10 (Ubiquinone) is an endogenous anti-oxidant with anti-oxidant properties that aids to reduce oxidative stress. It boosts the anti-oxidant activity of superoxide dismutase and glutathione peroxidase, reduces lipid peroxidation, neutralises free radicals, and promotes vitamin E and C regeneration in the body. It can be found in the form of ubiquinol or ubiquinone. CoQ10 may be found in both diet and supplements. It can be made as a syrup, tablet, soft gel capsule, hard shell capsule, or oral powder as a supplement. It is classified as a biopharmaceutical class II compound with low solubility but good permeability. When CoQ10 supplement is taken with a fatty meal, its bioavailability is increased. CoQ10 slows the evolution of obesity-related atherosclerosis and helps to mitigate the harmful bodily environment caused by obesity.
- Coenzyme Q10
- metabolic disorder
How to Cite
Mikailu S, Obomate NL, Ugochukwu OP, Ekenna IC. Anti-Inflammatory, Fibrinolytic and Anti-Oxidant Activities of the N-Hexane Extract of Ficus sur Forssk (Moraceae) Leaves. Haya: The Saudi Journal of Life Sciences. 2022;7(2):44-50.
Hall J. Dietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and Minerals. Guyton and Hall Textbook of Medical Physiology. 11 ed. Philadelphia: Saunders Elsevier; 2006. p. 865 -80.
Engin A. The definition and prevalence of obesity and metabolic syndrome. Obesity and lipotoxicity. 2017:1-17.
Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Annals of the New York Academy of Sciences. 2012;1271(1):37-43.
Wolin KY, Carson K, Colditz GA. Obesity and cancer. The oncologist. 2010; 15(6):556.
Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG. Coenzyme Q10 in cardiovascular and metabolic diseases: current state of the problem. Current cardiology reviews. 2018;14(3):164-74.
Barcelos IPd, Haas RH. CoQ10 and aging. Biology. 2019;8(2):28.
Portakal O, Özkaya Ö, Bozan B, Koşan M, Sayek I. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clinical biochemistry. 2000;33(4):279-84.
Tafazoli A. Coenzyme Q10 in breast cancer care. Future Oncology. 2017;13(11):1035-41.
Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque CM, Fernández-Riejo P, et al. Coenzyme Q10: A novel therapeutic approach for Fibromyalgia? Case series with 5 patients. Mitochondrion. 2011;11(4):623-5.
Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, et al. Can coenzyme Q10 improve clinical and molecular parameters in fibromyalgia? : Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA; 2013.
Mitton N. Coenzyme Q10/Ubiquinol/ Ubiquinone.
Hodgson J, Watts G, Playford D, Burke V, Croft K. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. European journal of clinical nutrition. 2002;56(11):1137-42.
Zhang S-y, Yang K-l, Zeng L-t, Wu X-h, Huang H-y. Effectiveness of coenzyme Q10 supplementation for type 2 diabetes mellitus: a systematic review and meta-analysis. International journal of endocrinology. 2018;2018.
Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, et al. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals. Journal of clinical lipidology. 2018;12(2):417-27. e5.
Allen RM, Vickers KC. Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. Am Heart Assoc; 2014.
Thomas SR, Leichtweis SB, Pettersson K, Croft KD, Mori TA, Brown AJ, et al. Dietary cosupplementation with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice. Arteriosclerosis, thrombosis, and vascular biology. 2001;21(4):585-93.
Mancuso M, Orsucci D, Calsolaro V, Choub A, Siciliano G. Coenzyme Q10 and neurological diseases. Pharmaceuticals. 2009;2(3):134-49.
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Archives of neurology. 2002;59(10):1541-50.
Prakash S, Sunitha J, Hans M. Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases. Indian journal of pharmacology. 2010;42(6):334.
Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466-7.
Rozen T, Oshinsky M, Gebeline C, Bradley K, Young W, Shechter A, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia. 2002;22(2):137-41.
Sândor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005;64(4):713-5.
Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. New England Journal of Medicine. 2017;376(3):254-66.
Bovolini A, Garcia J, Andrade MA, Duarte JA. Metabolic Syndrome Pathophysiology and Predisposing Factors. International Journal of Sports Medicine. 2021;42(03):199-214.
Rohde K, Keller M, la Cour Poulsen L, Blüher M, Kovacs P, Böttcher Y. Genetics and epigenetics in obesity. Metabolism. 2019;92:37-50.
Amugsi DA, Dimbuene ZT, Mberu B, Muthuri S, Ezeh AC. Prevalence and time trends in overweight and obesity among urban women: an analysis of demographic and health surveys data from 24 African countries, 1991–2014. BMJ open. 2017;7(10):e017344.
Manyanga T, El-Sayed H, Doku DT, Randall JR. The prevalence of underweight, overweight, obesity and associated risk factors among school-going adolescents in seven African countries. BMC Public Health. 2014;14(1):887.
Mielmann A. Proposed strategies for South African supermarkets to in-crease healthier food choices: a literature review. Journal of Consumer Sciences. 2019.
Popkin BM, Adair LS, Ng SW. Global nutrition transition and the pandemic of obesity in developing countries. Nutr Rev. 2012;70(1):3-21.
WHO. World Health Organization report of the commission on ending childhood obesity. Geneva, Switzerland: World Health Organization; 2016.
Mensah G. Ischaemic heart disease in Africa. Heart. 2008;94(7):836-43.
Redinger RN. The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol (N Y). 2007;3(11):856-63.
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Síndrome metabólica. A obesidade aumenta o estresse oxidativo e pode desencadear a síndrome metabólica. J Clin Invest. 2004;114(12):1752-61.
Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. Obesity-associated oxidative stress: strategies finalized to improve redox state. International journal of molecular sciences. 2013;14(5):10497-538.
Serra D, Mera P, Malandrino MI, Mir JF, Herrero L. Mitochondrial fatty acid oxidation in obesity. Antioxidants & redox signaling. 2013;19(3):269-84.
Bełtowski J. Leptin and the regulation of endothelial function in physiological and pathological conditions. Clinical and Experimental Pharmacology and Physiology. 2012;39(2):168-78.
Chrysohoou C, Panagiotakos DB, Pitsavos C, Skoumas I, Papademetriou L, Economou M, et al. The implication of obesity on total antioxidant capacity in apparently healthy men and women: the ATTICA study. Nutrition, Metabolism and Cardiovascular Diseases. 2007;17(8):590-7.
Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González Á, Esquivel-Chirino C, et al. Inflammation, oxidative stress, and obesity. International journal of molecular sciences. 2011;12(5):3117-32.
Manna P, Jain SK. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metabolic syndrome and related disorders. 2015; 13(10):423-44.
Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. International journal of obesity. 2006;30(3):400-18.
Olusi S. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. International journal of obesity. 2002;26(9):1159-64.
Ozata M, Mergen M, Oktenli C, Aydin A, Sanisoglu SY, Bolu E, et al. Increased oxidative stress and hypozincemia in male obesity. Clinical biochemistry. 2002;35(8): 627-31.
Vincent HK, Powers SK, Dirks AJ, Scarpace PJ. Mechanism for obesity-induced increase in myocardial lipid peroxidation. Int J Obes Relat Metab Disord. 2001;25(3):378-88.
Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007;7: S34-S40.
Mehmetoglu I, Yerlikaya FH, Kurban S. Correlation between vitamin A, E, coenzyme Q10 and degree of insulin resistance in obese and non-obese subjects. Journal of clinical biochemistry and nutrition. 2011;49(3):159-63.
Davì G, Guagnano MT, Ciabattoni G, Basili S, Falco A, Marinopiccoli M, et al. Platelet activation in obese women: role of inflammation and oxidant stress. Jama. 2002;288(16):2008-14.
Mutlu-Türkoğlu Ü, Öztezcan S, Telci A, Orhan Y, Aykac-Toker G, Sıvas A, et al. An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women. Clinical and experimental medicine. 2003;2(4):171-4.
Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5(4): 1218-40.
H Tomkin G, Owens D. LDL as a cause of atherosclerosis. The Open Atherosclerosis & Thrombosis Journal. 2012;5(1).
Steinberg D. Lewis A. Conner Memorial Lecture: oxidative modification of LDL and atherogenesis. Circulation. 1997;95(4): 1062-71.
Ochoa JJ, Pamplona R, Ramirez-Tortosa MC, Granados-Principal S, Perez-Lopez P, Naudí A, et al. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10. Free Radical Biology and Medicine. 2011;50(9):1053-64.
Gutierrez-Mariscal FM, Yubero-Serrano EM, Villalba JM, Lopez-Miranda J. Coenzyme Q10: From bench to clinic in aging diseases, a translational review. Critical reviews in food science and nutrition. 2019;59(14):2240-57.
Blatt T, Littarru GP. Biochemical rationale and experimental data on the antiaging properties of CoQ10 at skin level. Biofactors. 2011;37(5):381-5.
Ghaemi F, Azizi H, Sahebkar MS, Mehraban Moghadam S, Jarahi L, Safarian M, et al. The Effects of Acupuncture on the Glutathione System of Overweight and Obese Subjects. Journal of Nutrition, Fasting and Health. 2021.
Bakker S, Ijzerman R, Teerlink T. westerhoff HV, Gans RO, Heine RJ. Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure. Atherosclerosis. 2000;148:17-21.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane database of systematic reviews. 2012(3).
Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD (P) H oxidase in cultured vascular cells. Diabetes. 2000;49(11): 1939-45.
Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, et al. Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. Elife. 2018;7: e32111
Sohet FM, Delzenne NM. Is there a place for coenzyme Q in the management of metabolic disorders associated with obesity? Nutrition reviews. 2012;70(11): 631-41.
Butler MG, Dasouki M, Bittel D, Hunter S, Naini A, DiMauro S. Coenzyme Q10 levels in Prader‐Willi syndrome: Comparison with obese and non‐obese subjects. American Journal of Medical Genetics Part A. 2003;119(2):168-71.
Bour S, Carmona M-C, Galinier A, Caspar-Bauguil S, Van Gaal L, Staels B, et al. Coenzyme Q as an antiadipogenic factor. Antioxidants & redox signaling. 2011; 14(3): 403-13.
Alam MA, Rahman MM. Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metab Disord. 2014; 13:60.
Pravst I, Rodríguez Aguilera JC, Cortes Rodriguez AB, Jazbar J, Locatelli I, Hristov H, et al. Comparative bioavailability of different coenzyme Q10 formulations in healthy elderly individuals. Nutrients. 2020;12(3):784.
Martinefski M, Samassa P, Buontempo F, Höcht C, Lucangioli S, Tripodi V. Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy. Journal of Pharmacy and Pharmacology. 2017;69(5):567-73.
Bhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006;40(5):445-53.
Liu Z-X, Artnuin C. Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Alternative Therapies in Health & Medicine. 2009;15(2):42.
Hidaka T, Fujii K, Funahashi I, Fukutomi N, Hosoe K. Safety assessment of coenzyme Q10 (CoQ10). Biofactors. 2008; 32(1‐4):199-208.
Temova Rakuša Ž, Kristl A, Roškar R. Stability of Reduced and Oxidized Coenzyme Q10 in Finished Products. Antioxidants. 2021;10(3):360.
López-Lluch G, del Pozo-Cruz J, Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas P. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. 2019;57:133-40.
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