Asian Journal of Research in Medical and Pharmaceutical Sciences

Sodium Lauryl Sulfate (SLS), a common anionic surfactant and emulsifier used in pharmaceuticals and household products. While SLS enhances the solubility of poorly soluble drugs, it may cause significant adverse effects, including skin irritation, damage to biological membranes, and potential disturbance to microbial balance. Various studies indicate that prolonged or high-concentration exposure can lead to skin barrier dysfunction and conditions like eczema, particularly in sensitive individuals. Moreover, the pharmacokinetics of SLS reveal limited dermal penetration but considerable urinary excretion after topical application.  Additionally, evidence suggests that SLS may contribute to serious health issues such as neurotoxicity and organ toxicity when absorbed in significant amounts. The paper discusses, including the mechanism of action, pharmacokinetics and toxicity to recognize SLS-related health problems. It stresses the necessity for increased awareness and regulation of SLS usage, advocating for safer alternatives and improved labelling to safeguard public health.