Efficacy of METFORMIN Alone versus Its Combination with SIMVASTATIN in the Management of Polycystic Ovary
Summer Fatima *
Pak Red Cresent Medical and Dental College, Lahore, Pakistan
Maha Sanam
District Headquarters (DHQ) Teaching Hospital, Sahiwal Medical College, Medical College Road, Sahiwal, Pakistan
Sehrish Khan
Akhtar Saeed Medical and Dental College, Lahore, Pakistan
*Author to whom correspondence should be addressed.
Abstract
Aims: To compare the effectiveness of treatment with METFORMIN alone and with a combination of METFORMIN and SIMVASTATIN in the management of polycystic ovarian syndrome.
Study Design: Randomized Clinical Trial.
Place and Duration of Study: Department of Obstetrics and Gynecology (Infertility Unit) at District Headquarter (DHQ) Teaching Hospital, Sahiwal (Pakistan) during June to September, 2018.
Methodology: 162 patients were randomly divided into METFORMIN group (n=81) and METFORMIN plus SIMVASTATIN group (n=81), detailed clinical history, including menstrual details, was taken with thorough examination performed. Baseline ultrasound was performed to evaluate the ovarian size and these were considered enlarged with volume >10cc or with >12 follicles in any one ovary. Blood samples were taken at baseline and after three months of therapy to determine the LH/FSH ratio and lipid profile. Efficacy was defined as >15% decrease in the baseline values.
Results: The mean age of the patients was 27.12 ±8.17 years, and the mean BMI was 24.21 ±2.2 Kg/m2. Efficacy was achieved in 67.1% patients with METFORMIN alone, while in 92.6% with combination medication (p=0.0068).
Conclusion: Managing the women having PCOS with the combination of METFORMIN and SIMVASTATIN is more beneficial as compared to treatment with METFORMIN alone.
Keywords: Polycystic ovarian syndrome, PCOS, METFORMIN, SIMVASTATIN