Asian Journal of Research in Medical and Pharmaceutical Sciences 2021-04-14T19:21:32+00:00 Asian Journal of Research in Medical and Pharmaceutical Scie Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Medical and Pharmaceutical Sciences&nbsp;(ISSN: 2457-0745)</strong>&nbsp;aims to publish research papers, reviews and short communications in the areas of&nbsp;medical and pharmaceutical sciences. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. This journal will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. This journal is novelty attracting, open-minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> Telemedicine in Covid-19: Challenges and Opportunities 2021-04-14T19:21:30+00:00 Imrana Masood Ummul Baneen . Nivedita <p>The pandemic of COVID -19 is a healthcare emergency of International concern. It originated in Wuhan, China in December 2019 and was declared as pandemic by WHO on 12 March 2020. Since then it is raging relentlessly across the world with staggering more than 60 lakh cases in India currently. This has put a tremendous strain on already frail and overburdened Indian healthcare system and aggravated concern in the accessibility to healthcare by common mass due to prevailing lockdown conditions. This has sparkled to re-think and renew the policy on healthcare and focus on relevance, reach and utilize the potential of telemedicine services for the delivery of healthcare to community. This term telemedicine has been in use since 1970s but became fully operational globally in early 2000. Now about 20 years later we find a revolutionary change in the focus of health services delivery towards community healthcare and wellbeing In this article we aim to analyze the difficulties and hurdles faced by non COVID patients and challenges in front of the government to dispense basic healthcare to those in need. We need to tap all our resources particularly ICT for healthcare delivery and use this adversity of COVID 19 pandemic as an opportunity to build on our capacity and expertise in the area of Telemedicine for the betterment of community healthcare.</p> 2021-04-06T00:00:00+00:00 ##submission.copyrightStatement## Factors Associated with Prognosis of Non-Alcoholic Fatty Liver Disease 2021-04-14T19:21:32+00:00 Muamar M. A. Shaheen Mohanad Saleh Deema Sider Reem Al Natsheh Raghad Dweik <p><strong>Background:</strong> At the junction between obesity, metabolic syndrome and liver failure, lies Non-alcoholic fatty liver disease. Recent studies elaborated on role of metformin in patients with non-alcoholic fatty liver disease. This observation has not been studied at a global scale, neither it was investigated in different ethnical groups.</p> <p><strong>Objectives:</strong> We aim at determining the risk factors associated with prognosis of non-alcoholic fatty liver disease among a cohort of patients in Southern West Bank, Palestine.</p> <p><strong>Methods:</strong> A retrospective cohort study involving 300 NAFLD patients who visited the internal medicine department at Hebron Governmental Hospital from October 2017 till September 2018. Two hundred and three patients diagnosed with non-alcoholic fatty liver disease, were included in this study. Lab test results within the past 6 months, comorbidity and medication history were collected from patients` profiles. Data was analyzed using SPSS V20. Liver Fibrosis score was determined by using non-alcoholic fatty liver disease fibrosis score calculator.</p> <p><strong>Results:</strong> Two hundred and three non-alcoholic fatty liver disease patients (58.6% females), 54.78 (±12.27) years old were included in the study. Almost 65.5% of these patients have BMI &gt;30 Kg/m<sup>2</sup>. It was found that, 62.25% of the 58 diabetic patients in this study had liver fibrosis score &gt; 0.676 comparing to non-alcoholic fatty liver disease patients who are non-diabetic. There was a significant relationship between diabetes and fibrosis score, α=0.000. There was also a significant relationship between hyperlipidemia and fibrosis score of non-alcoholic fatty liver disease patients, α=0.023. We found a significant relationship between fibrosis score and hypertension, α=0.000. In the same context, there was a significant relationship between NAFLD patients who were on statin therapy and those who were not using statin therapy, α= 0.015. Metformin was not associated with significant relationship between users and non-users non-alcoholic fatty liver disease subjects.</p> <p><strong>Conclusion</strong><strong>:</strong> Diabetes mellitus, hypertension, hyperlipidemia and statin use were associated with&nbsp; NAFLD prognosis.</p> 2021-03-16T00:00:00+00:00 ##submission.copyrightStatement## Evaluation of the Binding Properties of a Polymer Obtained from Modification of Triticum aestivum Starch in Metronidazole Tablets Formulation 2021-04-14T19:21:32+00:00 Nkemakolam Nwachukwu Kenneth Chinedu Ugoeze Azuka Ijoma Alumona <p><strong>Aim:</strong> The binding properties of a polymer obtained from modification of <em>Triticum aestivum</em> (TA) starch in metronidazole tablets formulation were evaluated.</p> <p><strong>Study Design:</strong> Experimental design.</p> <p><strong>Place and Duration of Study: </strong>Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria from January to July, 2018.</p> <p><strong>Methods:</strong> TA seeds were steeped for 72 h, wet milled and the native <em>Triticum aestivum</em> starch (NTS) extracted. NTS (1kg) was oxidized by slurring in 4 L of 3.50% w/v sodium hypochlorite, washed to neutral pH with 95% v/v ethanol (MTS). MTS was dried at 60°C for 3 h, milled and classified (250 μm). The starches were characterized using standard methods and applied as binders at 1, 2 and 3% w/w in formulating metronidazole tablets using wet granulation. Methylcellulose and gelatin at similar concentrations were used as standards.</p> <p><strong>Results:</strong> The granules and tablets were evaluated using standard methods. NTS and MTS had similar properties with starch. The modification improved the densities, hydration capacity and flow properties of MTS. The granules flowed and compressed well. The tablets had minimal weight variation, hardness (≥ 4 kgF), friability (&lt;1%) and disintegration (&lt;15 min). Metronidazole release (≥ 85%) within 60 min existed in all the batches except batches containing 1% methylcellulose and 3% gelatine.</p> <p><strong>Conclusion:</strong> The results met with United States Pharmacopoeia specifications for oral uncoated metronidazole tablets. MTS performed better than NTS and compared well with methylcellulose and gelatin as binder in metronidazole tablet formulation.</p> 2021-03-17T00:00:00+00:00 ##submission.copyrightStatement##