Asian Journal of Research in Medical and Pharmaceutical Sciences https://journalajrimps.com/index.php/AJRIMPS <p style="text-align: justify;"><strong>Asian Journal of Research in Medical and Pharmaceutical Sciences&nbsp;(ISSN: 2457-0745)</strong>&nbsp;aims to publish research papers, reviews and short communications in the areas of&nbsp;medical and pharmaceutical sciences. This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. This journal will not only publish traditional full research reports, including short communications, but also this journal will publish reports/articles on all stages of the research process like study protocols, pilot studies and pre-protocols. This journal is novelty attracting, open-minded, peer-reviewed medical periodical, designed to serve as a perfectly new platform for both mainstream and new ground shaking works as long as they are technically correct and scientifically motivated.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalajrimps.com (Asian Journal of Research in Medical and Pharmaceutical Scie) contact@journalajrimps.com (Asian Journal of Research in Medical and Pharmaceutical Scie) Thu, 30 Jul 2020 05:38:16 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Effect of Aqueous Ethanol Stem Extract of Entada africana Guill. Et Perrott. on Castor Oil and Magnesium Sulphate-Induced Diarrhoea Models in Mice https://journalajrimps.com/index.php/AJRIMPS/article/view/30146 <p>This study investigated the phytochemical, elemental analysis, acute toxicity study of aqueous ethanol stem bark extract of <em>Entada africana</em>, as well as its antidiarrhoeal activity in mice and its effects on isolated rabbit jejunum. The preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, cardiac glycosides, phenols, saponins, steroids, tannins and terpenoids. Elemental analysis of the extract showed the presence of magnesium (Mg), manganese (Mn), iron (Fe), copper (Cu), lead (Pb), zinc (Zn) and sodium (Na) while acute toxicity study revealed intraperitoneal median lethal dose (LD<sub>50</sub>) values for the extract to be 774.6 mg/kg body weight. The antidiarrheal effect of the extract was studied using castor-oil and magnesium sulphate induced diarrhoeal models (dropping test) and gastrointestinal transit test in mice. The result showed that the extract produced a dose-dependent protection against diarrhoea induced by castor oil and magnesium sulfate, with the highest protection (80 and 100%), obtained at 100 and 200 mg/kg. The extract significantly (p≤0.01) reduced the small intestinal transit of charcoal meal in mice at all doses tested. The extract (0.4-3.2 mg/ml) produced a concentration dependent relaxation of the rabbit jejunum, and the effects were blocked by propranolol (0.04 and 0.64 μg/ml). The results of this study showed that the extract contain pharmacologically active substance with antidiarrhoeal properties mediated through inhibition of hyper secretion and reduced gastrointestinal motility. These properties may explain the rationale for use of it’s stem bark as antidiarrhoeal remedy in traditional medicine.</p> Abubakar Bilyamini Mu’azu, Muhammad Ibrahim Usman ##submission.copyrightStatement## https://journalajrimps.com/index.php/AJRIMPS/article/view/30146 Thu, 30 Jul 2020 00:00:00 +0000 Acid Neutralizing Capacity of Selected Antacid Suspensions Available in the Ghanaian Market https://journalajrimps.com/index.php/AJRIMPS/article/view/30148 <p>Antacids are substances commonly used by patients to obtain fast symptomatic relief from dyspepsia. They are weak bases which neutralize excess gastric acid and subsequently raise the pH of the gastric contents. The potency of the antacids depends mainly on their acid neutralization capacity (ANC) and this can vary from one brand to another. Several dosage forms of antacids are available for use by patients. However, In Ghana, suspensions are the commonest dosage form of antacids which is preferred by patients.</p> <p>The objective of this study was to determine the acid neutralizing capacity of six (6) randomly selected brands of antacid suspensions on the Ghanaian market using potentiometric acid-base titration. The samples were coded A-F to avoid any bias in the study. All the sampled brands had more than one year to expiry as indicated on their label.</p> <p>Brand D had the highest ANC of 29.70 mEq/dose whiles brand A had the lowest ANC of 11.25 mEq/dose. From the results obtained, it can be inferred that acid neutralization can be more effective and rapidly achieved with liquid antacids containing a high amount of magnesium hydroxide and aluminium Hydroxide. Hence, for acute symptomatic relief from dyspepsia, antacids containing a higher concentration of magnesium hydroxide and aluminium hydroxide would be most beneficial to patients.</p> Cedric Dzidzor Kodjo Amengor, Owusu Frederick William Akuffo, James Kwaning, Albara Halidu Iddrisu, Alexander Ohemeng, Darinple Acquah Acheampomaa, Patience Gyapong ##submission.copyrightStatement## https://journalajrimps.com/index.php/AJRIMPS/article/view/30148 Tue, 08 Sep 2020 00:00:00 +0000